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Baricitinib(巴瑞替尼)的注意事项和用药禁忌症

发布时间:2023-12-15 10:23:50 阅读:1303 来源:问药网
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巴瑞替尼片

巴瑞替尼片 生产厂家:孟加拉伊思达(Incepta)制药有限公司 功能主治:JAK1/2抑制剂,用于多种炎症性疾病和自身免疫性疾病 用法用量:用法用量  1、类风湿性关节炎  OLUMIANT的推荐剂量为每日1次口服2mg,餐前餐后都可。  OLUMIANT可以单独使用,也可以与甲氨蝶呤或其他非生物dmard联合使用。  2、COVID-19(新冠病毒)  成人OLUMIANT的推荐剂量为每日一次口服4mg,餐前餐后都可,持续14天或直到出院,以先发生者为准。  3、斑秃  OLUMIANT的推荐剂量是2mg,每天一次口服,餐前餐后都可。  如果对治疗的反应不充分,增加到每天一次4mg。  对于几乎完全或完全的头皮脱发,睫毛或眉毛有或没有大量脱发的患者,考虑每天一次4mg治疗,伴餐前餐后都可。  一旦患者对4mg的治疗产生了充分的反应,将剂量减少到2mg,每天一次。  对于无法吞下整片药片的患者,可以考虑另一种给药方式:  1、口服分散  2、胃造口管(G管)  3、鼻胃管(NG管)或口胃管(OG管)
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Baricitinib(巴瑞替尼)的注意事项和用药禁忌症,Baricitinib(Baricitinib)用于治疗中至重度活动性类风湿关节炎和某些病毒感染,使用时的注意事项包括:1.感染风险:监测感染迹象,因为巴瑞替尼可能增加感染风险。2.血液监测:定期检查血细胞计数,尤其是淋巴细胞和中性粒细胞。3.肝功能检测:定期进行肝功能检测。4.血脂监测:可能需要监测血脂水平。5.肺炎球菌和流感疫苗:建议接种疫苗,尤其是在治疗前。

Baricitinib (巴瑞替尼) is a medication that is used for the treatment of rheumatoid arthritis, COVID-19, and alopecia areata. However, like any medication, there are important precautions and contraindications to consider before using it. In this article, we will explore the necessary precautions and contraindications associated with Baricitinib.

1. Precautions for Baricitinib:

Baricitinib should be used with caution, and it is essential to consider the following precautions:

a. Infections: Baricitinib may increase the risk of developing serious infections. Before starting treatment, patients should be evaluated for underlying infections, and if necessary, these infections should be treated prior to initiating Baricitinib therapy. Patients should also be monitored for signs and symptoms of infections during treatment, and prompt medical attention should be sought if any signs of infection occur.

b. Thrombosis: There have been reports of blood clots, including deep vein thrombosis and pulmonary embolism, in some patients taking Baricitinib. Patients with a history of blood clotting disorders or those at an increased risk of developing blood clots should be closely monitored while on Baricitinib therapy. Any signs of blood clot formation, such as swelling, pain, or redness in the limbs, chest pain, or shortness of breath, should be reported to a healthcare professional immediately.

c. Malignancies: Patients on Baricitinib may have an increased risk of developing certain types of cancers. Regular monitoring and screening for malignancies should be conducted according to standard guidelines.

d. Liver function: Baricitinib can affect liver function. It is recommended to monitor liver function tests in patients taking this medication. If there are any significant abnormalities in liver function, the treatment should be discontinued.

2. Contraindications for Baricitinib:

There are certain medical conditions and medications that are contraindicated with Baricitinib. These include:

a. Hypersensitivity: Baricitinib should not be used in individuals who have a known hypersensitivity or allergy to the medication.

b. Severe liver impairment: Individuals with severe liver impairment should avoid using Baricitinib as it may further worsen the condition.

c. Pregnancy and breastfeeding: The safety of Baricitinib has not been established during pregnancy or breastfeeding. Therefore, it is generally not recommended for use in pregnant or breastfeeding women.

d. Strong immunosuppressive medications: Baricitinib should not be combined with certain strong immunosuppressive medications, as this can increase the risk of immunosuppression-related complications.

It is crucial to note that this article provides a general overview of the precautions and contraindications associated with Baricitinib. It is important to consult with a healthcare professional or read the prescribing information provided with the medication for comprehensive and personalized information.

In conclusion, Baricitinib is a medication used for various conditions, including rheumatoid arthritis, COVID-19, and alopecia areata. However, it is essential to consider the precautions and contraindications associated with its use to ensure the safety and well-being of patients. By following the necessary precautions and avoiding contraindications, healthcare professionals can help maximize the benefits and minimize the risks associated with Baricitinib therapy.