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Ambisome(安必素)有副作用吗

发布时间:2023-12-20 11:12:35 阅读:1236 来源:问药网
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安必素

安必素 生产厂家:迈兰(Mylan)制药有限公司 功能主治:一线抗真菌药物,治疗深部真菌感染有效率高 用法用量:用法用量  静脉用药:开始静脉滴注时先试以1~5mg或按体重一次0.02~0.1mg/kg给药,以后根据患者耐受情况每日或隔日增加5mg,当增至一次 0.6~0.7mg/kg时即可暂停增加剂量,此为一般治疗量。  成人最高一日剂量不超过1mg/kg,每日或隔1~2日给药1次,累积总量 1.5~3.0g,疗程1~3个月,也可长至6个月,视病情及疾病种类而定。  对敏感真菌感染宜采用较小剂量,即成人一次20~30mg,疗程仍宜长。  鞘内给药:首次0.05~0.1mg,以后渐增至每次0.5mg,最大量一次不超过1mg,每周给药2~3次,总量15mg左右。  鞘内给药时宜与小剂量地塞米松或琥珀酸氢化可的松同时给与,并需用脑脊液反复稀释药液,边稀释边缓慢注入以减少不良反应。  局部用药:气溶吸入时成人每次5~10mg,用灭菌注射用水溶解成0.2%~0.3%溶液应用;超声雾化吸入时本品浓度为0.01%~0.02%,每日吸入2~3次,每次吸入5~10ml;持续膀胱冲洗时每日以两性霉素B 5mg加入1000ml灭菌注射用水中,按每小时注入40ml速度进行冲洗,共用5~10日。  静脉滴注或鞘内给药时,均先以灭菌注射用水10ml配制本品50mg,或5ml配制25mg,然后用5%葡萄糖注射液稀释(不可用氯化钠注射液,因可产生沉淀),滴注液的药物浓度不超过10mg/100ml,避光缓慢静滴,每次滴注时间需6小时以上,稀释用葡萄糖注射液的pH值应在4.2以上。  鞘内注射时可取5mg/ml浓度的药液1ml,加5%葡萄糖注射液19ml稀释,使最终浓度成250μg/ml。  注射时取所需药液量以脑脊液5~30ml反复稀释,并缓慢注入。  鞘内注射液的药物浓度不可高于25mg/100ml,pH值应在4.2以上。
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Ambisome(安必素)有副作用吗,Ambisome(AmBisome)常见副作用包括发热、寒战、呼吸困难、恶心、呕吐、肾功能损害、低钾血症、头痛和胃肠不适。在治疗期间需要监测肾功能和电解质。Ambisome(AmBisome)是一种抗真菌药物,其主要成分是阿莫夫洛星(AmphotericinB)。它主要用于治疗严重的真菌感染,具有以下疗效:1.抗真菌活性,抑制多种真菌的生长和繁殖。2.治疗各种念珠菌感染。3.治疗血液系统真菌感染。该药品在治疗相关疾病方面表现出色,疗效显著、安全性高。

Ambisome (安必素) is a medication used to treat fungal infections. Now, let's delve into whether Ambisome has any side effects.

1. Introduction to Ambisome and its Purpose

Ambisome is a brand name for amphotericin B, a potent antifungal drug. It is primarily used to treat serious fungal infections caused by various species of fungi. This medication is commonly prescribed when infections do not respond to other antifungal medications or when patients are unable to tolerate other treatments. Ambisome works by inhibiting the growth and reproduction of fungal cells, thereby helping the body fight off the infection.

2. Common Side Effects of Ambisome

Like most medications, Ambisome may cause some side effects in patients. However, it is important to note that not everyone will experience these side effects, and the severity can vary from person to person. The most commonly reported side effects of Ambisome include:

1. Fever and chills: Patients may experience flu-like symptoms, such as a fever and chills, during or shortly after receiving Ambisome infusions.

2. Headache: Some individuals may experience headaches while taking Ambisome. These headaches are usually mild and subside on their own.

3. Nausea and vomiting: Ambisome can cause gastrointestinal disturbances, leading to feelings of nausea and occasional vomiting.

4. Muscle or joint pain: Certain patients may experience muscle or joint pain while undergoing treatment with Ambisome.

5. Skin reactions: In rare cases, Ambisome can cause skin rashes, itching, or other allergic reactions.

3. Less Common and Severe Side Effects

While the aforementioned side effects are the most commonly observed, Ambisome may also cause less common but more severe side effects. These side effects should be reported to a healthcare professional immediately if they occur. They may include:

1. Severe allergic reactions: Some individuals may experience serious allergic reactions to Ambisome. Symptoms may include swelling of the face, tongue, or throat; difficulty breathing or swallowing; and hives.

2. Kidney damage: Ambisome can cause kidney damage in some patients, leading to changes in urine output, confusion, swelling in the legs or ankles, and fatigue.

3. Liver problems: In rare cases, Ambisome may cause liver problems, resulting in jaundice (yellowing of the skin and eyes), dark urine, pale stools, and abdominal pain.

4. Blood disorders: Ambisome can affect blood cells, leading to anemia, low platelet count (increased risk of bleeding), and low white blood cell count (increased risk of infections).

4. Precautions and Conclusion

It is crucial to discuss your medical history and any underlying conditions with your healthcare provider before starting treatment with Ambisome. This will help your doctor assess the potential risks and benefits of the medication for your specific situation. They will be able to monitor your progress closely and address any concerns that may arise during your treatment.

In conclusion, Ambisome is an effective antifungal medication used to treat serious fungal infections. While it may cause some side effects, they are usually manageable and temporary. It is important to report any unusual or severe symptoms to your healthcare provider to ensure your safety and well-being throughout the treatment process.