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Ambisome(安必素)说明书

发布时间:2023-12-25 13:01:13 阅读:1239 来源:问药网
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安必素

安必素 生产厂家:美国吉利德科学公司(Gilead Sciences) 功能主治:一线抗真菌药物,治疗深部真菌感染有效率高 用法用量:用法用量  静脉用药:开始静脉滴注时先试以1~5mg或按体重一次0.02~0.1mg/kg给药,以后根据患者耐受情况每日或隔日增加5mg,当增至一次 0.6~0.7mg/kg时即可暂停增加剂量,此为一般治疗量。  成人最高一日剂量不超过1mg/kg,每日或隔1~2日给药1次,累积总量 1.5~3.0g,疗程1~3个月,也可长至6个月,视病情及疾病种类而定。  对敏感真菌感染宜采用较小剂量,即成人一次20~30mg,疗程仍宜长。  鞘内给药:首次0.05~0.1mg,以后渐增至每次0.5mg,最大量一次不超过1mg,每周给药2~3次,总量15mg左右。  鞘内给药时宜与小剂量地塞米松或琥珀酸氢化可的松同时给与,并需用脑脊液反复稀释药液,边稀释边缓慢注入以减少不良反应。  局部用药:气溶吸入时成人每次5~10mg,用灭菌注射用水溶解成0.2%~0.3%溶液应用;超声雾化吸入时本品浓度为0.01%~0.02%,每日吸入2~3次,每次吸入5~10ml;持续膀胱冲洗时每日以两性霉素B 5mg加入1000ml灭菌注射用水中,按每小时注入40ml速度进行冲洗,共用5~10日。  静脉滴注或鞘内给药时,均先以灭菌注射用水10ml配制本品50mg,或5ml配制25mg,然后用5%葡萄糖注射液稀释(不可用氯化钠注射液,因可产生沉淀),滴注液的药物浓度不超过10mg/100ml,避光缓慢静滴,每次滴注时间需6小时以上,稀释用葡萄糖注射液的pH值应在4.2以上。  鞘内注射时可取5mg/ml浓度的药液1ml,加5%葡萄糖注射液19ml稀释,使最终浓度成250μg/ml。  注射时取所需药液量以脑脊液5~30ml反复稀释,并缓慢注入。  鞘内注射液的药物浓度不可高于25mg/100ml,pH值应在4.2以上。
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Ambisome(安必素)说明书,Ambisome(AmBisome)是一种抗真菌药物,其主要成分是阿莫夫洛星(AmphotericinB)。它主要用于治疗严重的真菌感染,具有以下疗效:1.抗真菌活性,抑制多种真菌的生长和繁殖。2.治疗各种念珠菌感染。3.治疗血液系统真菌感染。该药品在治疗相关疾病方面表现出色,疗效显著、安全性高。

Ambisome (安必素) is a medication used in the treatment of fungal infections. It belongs to a category of drugs known as antifungal agents and is commonly used in cases where other antifungal medications have proven ineffective. In this article, we will provide a comprehensive guide to Ambisome, including its uses, dosage, side effects, and precautions.

1. What is Ambisome?

Ambisome is an antifungal medication that contains the active ingredient amphotericin B. It is administered intravenously and is used to treat severe systemic fungal infections, including invasive aspergillosis, candidemia, and cryptococcal meningitis. Ambisome works by disrupting the cell membrane of the fungal organisms, leading to their death.

2. Dosage and Administration

The dosage and administration of Ambisome may vary depending on the specific infection being treated, the patient's weight, and kidney function. It is typically administered intravenously once daily, with the infusion taking place over a period of one to two hours. The duration of the treatment is determined by the severity and type of infection. It is essential to follow the prescribed dosage and administration instructions provided by a healthcare professional.

3. Side Effects

As with any medication, Ambisome can cause side effects. Common side effects include fever, shaking or chills, headache, nausea, vomiting, and muscle or joint pain. These side effects are usually temporary and subside on their own. However, if any side effect is persistent or severe, it is important to inform a healthcare professional promptly. In rare cases, Ambisome may cause serious side effects, such as kidney damage or allergic reactions. Immediate medical attention should be sought if any signs of an allergic reaction, such as rash, itching, or difficulty breathing, occur.

4. Precautions and Considerations

Before using Ambisome, it is important to inform your healthcare provider about any existing medical conditions or allergies. Certain medications or pre-existing conditions may interact with Ambisome or increase the risk of side effects. It is particularly crucial to notify your healthcare provider if you have kidney problems, liver disease, or low potassium or magnesium levels. Pregnant or breastfeeding women should discuss the potential risks and benefits of Ambisome with their healthcare provider.

In conclusion, Ambisome is a vital medication used in the treatment of severe systemic fungal infections. It is vital to follow the prescribed dosage and administration instructions provided by a healthcare professional. While Ambisome may cause side effects, most of them are temporary and subside on their own. However, it is crucial to seek immediate medical attention for any persistent or severe side effects. By understanding the uses, dosage, and precautions associated with Ambisome, patients can make informed decisions about their treatment and maximize its effectiveness.