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Ambisome(安必松)安必素的用法用量及剂量修改

发布时间:2025-01-31 11:16:42 阅读:1755 来源:问药网
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安必素

安必素 生产厂家:美国吉利德科学公司(Gilead Sciences) 功能主治:一线抗真菌药物,治疗深部真菌感染有效率高 用法用量:用法用量  静脉用药:开始静脉滴注时先试以1~5mg或按体重一次0.02~0.1mg/kg给药,以后根据患者耐受情况每日或隔日增加5mg,当增至一次 0.6~0.7mg/kg时即可暂停增加剂量,此为一般治疗量。  成人最高一日剂量不超过1mg/kg,每日或隔1~2日给药1次,累积总量 1.5~3.0g,疗程1~3个月,也可长至6个月,视病情及疾病种类而定。  对敏感真菌感染宜采用较小剂量,即成人一次20~30mg,疗程仍宜长。  鞘内给药:首次0.05~0.1mg,以后渐增至每次0.5mg,最大量一次不超过1mg,每周给药2~3次,总量15mg左右。  鞘内给药时宜与小剂量地塞米松或琥珀酸氢化可的松同时给与,并需用脑脊液反复稀释药液,边稀释边缓慢注入以减少不良反应。  局部用药:气溶吸入时成人每次5~10mg,用灭菌注射用水溶解成0.2%~0.3%溶液应用;超声雾化吸入时本品浓度为0.01%~0.02%,每日吸入2~3次,每次吸入5~10ml;持续膀胱冲洗时每日以两性霉素B 5mg加入1000ml灭菌注射用水中,按每小时注入40ml速度进行冲洗,共用5~10日。  静脉滴注或鞘内给药时,均先以灭菌注射用水10ml配制本品50mg,或5ml配制25mg,然后用5%葡萄糖注射液稀释(不可用氯化钠注射液,因可产生沉淀),滴注液的药物浓度不超过10mg/100ml,避光缓慢静滴,每次滴注时间需6小时以上,稀释用葡萄糖注射液的pH值应在4.2以上。  鞘内注射时可取5mg/ml浓度的药液1ml,加5%葡萄糖注射液19ml稀释,使最终浓度成250μg/ml。  注射时取所需药液量以脑脊液5~30ml反复稀释,并缓慢注入。  鞘内注射液的药物浓度不可高于25mg/100ml,pH值应在4.2以上。
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Ambisome(安必松)安必素的用法用量及剂量修改,Ambisome(AmBisome)建议在新的治疗疗程之前给予测试剂量。可以服用少量的AmBisome输液(例如1mg)约10分钟,然后停止服用,并在接下来的30分钟内仔细观察患者。如果没有严重的过敏或类过敏反应,则可以继续输注AmBisome剂量。

Ambisome (安必松) is a medication used to treat fungal infections. It is classified as an antifungal agent and is commonly prescribed for the management of serious fungal infections, including those caused by Candida species, Aspergillus species, and Cryptococcus neoformans. This article provides information about the usage, dosage, and modifications of Ambisome.

1. Introduction:

Ambisome is a widely used antifungal medication that plays a crucial role in combating fungal infections in patients. Understanding how to appropriately administer this medication is essential for effective treatment.

2. Proper Usage of Ambisome:

Ambisome is administered intravenously (IV), meaning it is delivered directly into the bloodstream through a vein. It should only be administered under the supervision of healthcare professionals, such as doctors or trained nurses. The dosage of Ambisome varies depending on the specific fungal infection being treated, the patient's overall health, and other factors. It is essential to follow the dosage instructions provided by the prescribing healthcare professional carefully.

3. Determining the Dosage:

The dosage of Ambisome is typically determined based on the patient's weight, renal function, and the severity of the infection. In general, the recommended dosage of Ambisome for adults is 3-5 mg/kg of body weight per day. This dosage is usually divided and administered once daily or every other day. However, it's crucial to note that dosage recommendations can vary depending on individual patient factors, so it's important to rely on the guidance of a healthcare professional.

4. Dose Adjustment and Monitoring:

In some situations, dose adjustment of Ambisome may be necessary. Patients with impaired renal function or those receiving dialysis may require modified dosages. Additionally, close monitoring of renal function and serum electrolyte levels is crucial during Ambisome therapy to ensure safety and efficacy. Healthcare professionals will assess these factors and make appropriate dosage adjustments when necessary.

5. Potential Side Effects:

While Ambisome is generally well-tolerated, there are potential side effects to be aware of. Common side effects may include fever, chills, headache, nausea, vomiting, and infusion-related reactions. These adverse reactions should be reported to a healthcare professional promptly. Rare but severe side effects, such as kidney damage or liver problems, may occur. If any unusual symptoms or side effects occur during Ambisome treatment, immediate medical attention is necessary.

6. Conclusion:

Ambisome is a valuable medication for the treatment of serious fungal infections. Understanding its proper usage, dosage, and potential modifications is essential for healthcare professionals and patients. Always consult with a healthcare professional for accurate and individualized instructions on the usage and dosage of Ambisome, as they will consider the specific circumstances and needs of the patient to ensure the best possible outcomes.