首页 > 用药指导 > 文章详情

Ambisome(安必松)安必素功效与作用

发布时间:2025-02-11 08:52:13 阅读:1010 来源:问药网
分享至

分享到微信朋友圈

×

打开微信,点击底部的“发现”,

使用“扫一扫”即可将网页分享至朋友圈。

安必素

安必素 生产厂家:迈兰(Mylan)制药有限公司 功能主治:一线抗真菌药物,治疗深部真菌感染有效率高 用法用量:用法用量  静脉用药:开始静脉滴注时先试以1~5mg或按体重一次0.02~0.1mg/kg给药,以后根据患者耐受情况每日或隔日增加5mg,当增至一次 0.6~0.7mg/kg时即可暂停增加剂量,此为一般治疗量。  成人最高一日剂量不超过1mg/kg,每日或隔1~2日给药1次,累积总量 1.5~3.0g,疗程1~3个月,也可长至6个月,视病情及疾病种类而定。  对敏感真菌感染宜采用较小剂量,即成人一次20~30mg,疗程仍宜长。  鞘内给药:首次0.05~0.1mg,以后渐增至每次0.5mg,最大量一次不超过1mg,每周给药2~3次,总量15mg左右。  鞘内给药时宜与小剂量地塞米松或琥珀酸氢化可的松同时给与,并需用脑脊液反复稀释药液,边稀释边缓慢注入以减少不良反应。  局部用药:气溶吸入时成人每次5~10mg,用灭菌注射用水溶解成0.2%~0.3%溶液应用;超声雾化吸入时本品浓度为0.01%~0.02%,每日吸入2~3次,每次吸入5~10ml;持续膀胱冲洗时每日以两性霉素B 5mg加入1000ml灭菌注射用水中,按每小时注入40ml速度进行冲洗,共用5~10日。  静脉滴注或鞘内给药时,均先以灭菌注射用水10ml配制本品50mg,或5ml配制25mg,然后用5%葡萄糖注射液稀释(不可用氯化钠注射液,因可产生沉淀),滴注液的药物浓度不超过10mg/100ml,避光缓慢静滴,每次滴注时间需6小时以上,稀释用葡萄糖注射液的pH值应在4.2以上。  鞘内注射时可取5mg/ml浓度的药液1ml,加5%葡萄糖注射液19ml稀释,使最终浓度成250μg/ml。  注射时取所需药液量以脑脊液5~30ml反复稀释,并缓慢注入。  鞘内注射液的药物浓度不可高于25mg/100ml,pH值应在4.2以上。
查看详情

Ambisome(安必松)安必素功效与作用,Ambisome(AmBisome)是一种抗真菌药物,其主要成分是阿莫夫洛星(AmphotericinB)。它主要用于治疗严重的真菌感染,具有以下疗效:1.抗真菌活性,抑制多种真菌的生长和繁殖。2.治疗各种念珠菌感染。3.治疗血液系统真菌感染。该药品在治疗相关疾病方面表现出色,疗效显著、安全性高。

Ambisome (安必松) is a medication commonly used to treat fungal infections. It belongs to a class of drugs called liposomal amphotericin B formulations. Amphotericin B is an antifungal agent, and Ambisome is a specifically formulated version that offers improved efficacy and reduced side effects compared to traditional amphotericin B products. Ambisome is often used in the treatment of life-threatening fungal infections, such as invasive aspergillosis, systemic candidiasis, and cryptococcal meningitis, among others. Now, let's explore the efficacy and uses of Ambisome in more detail.

1. What is Ambisome?

Ambisome is a liposomal formulation of amphotericin B, which means it consists of amphotericin B encapsulated within tiny lipid spheres called liposomes. This formulation helps improve the drug's targeting and delivery to the site of infection while minimizing its toxicity to healthy tissues. As a result, Ambisome offers enhanced antifungal activity and has become the preferred choice for treating severe, systemic fungal infections.

2. Efficacy of Ambisome

Ambisome has demonstrated remarkable efficacy in the treatment of various fungal infections. It has shown superior efficacy compared to other antifungal agents in clinical trials. Ambisome is particularly effective against infections caused by fungi that are resistant to other antifungal medications or those that affect vulnerable patients, such as those with compromised immune systems. Its broad-spectrum activity makes it a valuable tool in combating life-threatening fungal infections.

3. Mechanism of Action

Ambisome works by binding to a substance called ergosterol, which is essential for the integrity of fungal cell membranes. By binding to ergosterol, Ambisome disrupts the fungal membrane, leading to leakage of cellular components and ultimately killing the fungus. The liposomal formulation of Ambisome helps the drug penetrate the fungal cells more effectively, enhancing its antifungal capabilities.

4. Uses of Ambisome

The primary use of Ambisome is in the treatment of severe systemic fungal infections. It is often prescribed when other antifungal medications have failed or when the infection is caused by a resistant fungus. Ambisome has shown efficacy in treating invasive aspergillosis, a potentially life-threatening infection commonly seen in immunocompromised patients. It is also effective against candidemia and other invasive candidiasis, which occur in patients with prolonged hospital stays, surgery, or indwelling catheters. Additionally, Ambisome is used in the treatment of cryptococcal meningitis, a severe fungal infection affecting the membranes surrounding the brain and spinal cord.

In conclusion, Ambisome— a liposomal formulation of amphotericin B— is a potent antifungal medication with broad-spectrum activity. Its superior efficacy and reduced toxicity make it a crucial tool in the treatment of severe fungal infections, particularly those resistant to other antifungal drugs. With its targeted delivery system and mechanism of action, Ambisome offers hope for patients battling life-threatening fungal infections. However, it is important to note that Ambisome is a prescription medication and should only be used under the guidance and supervision of a healthcare professional.